Quantitative assay for TALEN activity at endogenous genomic loci
نویسندگان
چکیده
منابع مشابه
Quantitative assay for TALEN activity at endogenous genomic loci
Artificially designed nucleases such as zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) can induce a targeted DNA double-strand break at the specific target genomic locus, leading to the frameshift-mediated gene disruption. However, the assays for their activity on the endogenous genomic loci remain limited. Herein, we describe a versatile modified lacZ...
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ژورنال
عنوان ژورنال: Biology Open
سال: 2013
ISSN: 2046-6390
DOI: 10.1242/bio.20133871